Colitis is a long-term inflammation of the colon and rectum. It is a painful and unpleasant disorder that affects the lining of the large intestine, which turns red from inflammation, shorter, often blood-filled accidents, and abdominal cramping. No one knows the exact cause, but there is evidence that colitis is the result of a complex interaction between genetic disposition and environmental, immune, social, psychological, and lifestyle factors. The treatment, which can include drugs that counter inflammation, dietary changes, and, in extreme cases, surgical removal of the inflamed portion of the colon, helps in alleviating the disease and leading to a better life.